Introducing "Rosetta", a group of software libraries for polymer modeling.
Rosetta is a flexible and highly functional library for accomplishing versatile biomolecule modeling tasks.
About Rosetta
A versatile and versatile polymer modeling software that helps you understand protein structure, protein design, protein docking, protein-DNA and protein-protein interactions.Apply algorithms and statistical methods to analyze large datasets of protein sequences, DNA, RNA, etc.In computational biology, de novo protein prediction (de novo), enzyme design, ligand docking calculation, and structure prediction of biopolymers and biopolymers are possible.
Rosetta can be used for experiments on a wide range of scales, not only for large datasets, but also for small datasets.
About the development of Rosetta
Rosetta started as a protein structure prediction tool in the laboratory of Dr. David Baker at the University of Washington.Today, it goes beyond the University of Washington and is being developed by members of Rosetta Commons, including government laboratories, research institutes, research centers, and partner companies.
The hub for Rosetta modeling software (Rosetta Commons)
https://www.rosettacommons.org/
Major features
Rosetta contains multiple functional modules such as RosettaAbinitio (de novo protein prediction) and RosettaDesign (identification of low free energy sequences for the backbone of the target protein), including proteins, RNA, DNA, peptides, small molecules, and non-proteins. Predict, design, and analyze a variety of biomolecular systems, including normal or derivatized amino acids.
Rosetta protocol example
- Rosetta Abinitio: deno vo Protein Structure Prediction
- RosettaDesign: Identification of low free energy sequences for the backbone of the target protein
- RosettaDock: Protein-Protein Complex Structure Prediction (Monomer)
- Rosetta DNA: For designing proteins that interact with specific DNA sequences
- RosettaRNA: RNA fragment assembly
- Rosetta Ligand: Small Molecule-Protein Docking
- RosettaEnzdes: Enzyme Design
- RosettaMatdes: Material design etc.
The source code for most protocols is written in C ++ or Python, or any other language, and uses Rosetta's flexible molecular modeling library to perform specific modeling tasks.These protocols can be self-contained, used in sequence to accomplish more complex tasks, combined with different applications, or chained together.
Rosetta application example
- Structure prediction: Loop modeling, RNA and RNA / protein
- docking: Antibodies, ligands, peptide docking
- Molecular design: Design of small molecules, RNA, DNA, secondary structure
- Membrane protein modeling
- analysis: Scoring, clustering, etc.
The beginning was to analyze the three-dimensional structure of a protein from the amino acid sequence of the protein (de novo protein structure prediction), but current applications are widely used, such as enzyme design to predict the amino acid sequence from the three-dimensional structure of an enzyme. I am.
* Available on Windows, Linux, and macOS.
About License
Rosetta has an academic license for academic, non-profit, and government agencies (Rosetta Academic License / Free of charge) And commercial licenses for commercial organizations (Commercial Licence) there is.
Pricing is based on the total number of FTEs (Full-Time Equivalents) for the entire company, not the number of users.There are two licensing options for global companies and organizations with fewer than 500 employees and 500 or more employees.Please consult with us regarding the language of the license agreement.
As of November 2023, Rosetta is available as an annual license.
How to contact
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- Download the license document and select the applicable product
There is a download button at the bottom of the manufacturer's website below.
https://els2.comotion.uw.edu/product/rosetta
- After filling in the required information and signing, the completed document will be sent to the developer. license@uw.edu Send to
- Download the license document and select the applicable product
- *Final review and signature will be done at UW CoMotion
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■ Click here for product details Please check the developer page for product details. Developer (University of Washington – CoMotion) Website |
