Metagenome analysis machine (February 2023 edition)

A customer involved in agriculture-related research asked us about a PC for performing metagenomic analysis.
We plan to use NGS data quality filtering, assembling, binning, KEGG and BLAST.
Your requirements are as follows.

・CPU: About Xeon Gold 6326
・ Memory: 512GB
・OS: Ubuntu
・Budget: Within 180 million yen
・Other: Use MetaWRAP and MetaSanity

I would like a spec that can use all the programs commonly used in metagenomic analysis.
Also, MetaWRAP needs a lot of memory capacity for assembly, so we hear that you want to give priority to memory capacity.

【Main Specifications】

CPU Xeon Gold 6326 (2.90GHz 16 cores)
memory 512GB
Storage 1 2TB SSD S-ATA x2
Storage 2 8TB HDD S-ATA x2
video Nvidia T1000
network On Board (1000Base-T X2)
Housing + power supply Tower type housing + 850W
OS Ubuntu 20.04

We considered the configuration according to the conditions of your request.
MetaWRAP is important to improve the CPU and memory specifications, so it seems that the CPU and memory conditions you request are a good choice that matches your budget.

In addition, MetaWRAP has a large database capacity of several hundred gigabytes in total, so the storage configuration is designed with this point in mind.

The configuration of this case study is based on the conditions given by the customer.
Please feel free to contact us even if you are considering different conditions from what is posted.

■FAQ

・What is metagenomic analysis?
Metagenome analysis is a method of comprehensively analyzing the genome of a community of microorganisms in the environment without culturing.From the gene sequence, it is possible to know the types of microorganisms living in the environment and their environmental functions.

・What is MetaWRAP?
MetaWRAP is software for metagenomic analysis.It can handle a variety of tasks such as read quality control, assembly, visualization, taxonomic profiling, and binning.

reference:MetaWRAP *Jumps to an external site

 

・What is MetaSanity?
MetaSanity is a software suite suitable for analyzing microbial genomes.It provides a unified workflow for genome evaluation and functional annotation, and can combine all outputs into a single queryable database.

reference:Meta Sanity *Jumps to an external site

 

・What is KEGG?
KEGG (Kyoto Encyclopedia of Genes and Genomes) understands the high-level function and utility of living systems such as cells, organisms and ecosystems from large-scale molecular datasets generated by genome sequencing and other high-throughput methods database resource for

reference:KEGG *Jumps to an external site

 

・What is BLAST?
BLAST (Basic Local Alignment Search Tool) is a high-speed homology search program.By searching a database or library with sequences at hand, it is possible to find similar sequence groups with scores above a certain threshold.

reference:BLAST *Jumps to an external site