Simulation software for research and development dealing with type 1 diabetes on the Unipos website UVA / Padova T1DMS (Type 1 Diabetes Metabolic Simulator) Page has been added.
UVA / Padova T1DMS is a computer simulator of the human metabolic system based on a dietary model of glucose-insulin kinetics, as an alternative to animal studies in preclinical trials of new treatment strategies for type 1 diabetes by the FDA in 2008. It is the first approved in silico diabetes model.
Its main use is to simulate tests of the same treatment protocol as the proposed clinical study, and to measure the effects on the management and treatment of diabetes, changing the amount and timing of meals and the dose and timing of insulin. In addition, the actual living environment is modeled so that hyperglycemia and hypoglycemia can be detected and measured.
T1DMS Software Overview
In silico population
- Embodies the biophysiological parameters of the FDA accepted in silico population
- 10 adults, 10 adolescents, 10 children
Basic user-defined simulation input
- Meal profiles (amount, timing and duration of a meal)
- Insulin treatment (amount and timing of basal / bolus insulin doses)
- Time of simulation and regulation (length & time of day)
- Hardware (pump & sensor)
- Control law definition in control algorithm
Fine-tuning treatment from subject-specific data
- Individualized, intra-personal results
- Inter-personal differences are revealed across the spectrum of human variation
- Population results are from the individual results calculated as in a clinical trial
- Age, Body Weight (kg), Subject-specific optimal basal insulin rate (u / hr), individual carbohydrate ratio (CR, g / U), total daily insulin, and insulin sensitivity (maximum drop in glucose mg / dl per unit of) insulin [MD])
- Metabolic testing results may be simulated for individual subjects and incorporated into treatment plans prior
Simulation service
- Simulation services using the 300 subject FDA-accepted population are available through The Epsilon Group
- To date, six IDE's have been granted by the FDA based on studies using the T1DMS
Simulation result data (by subject / by group)
- Blood glucose (BG) values and simulated sensor readings (mg / dl per minute)
- Basal / bolus insulin injections (pmol / minute)
- User-specified data from controller
- System states, carbohydrate intake and more…
Simulation result analysis
- Real-time glucose traces for visual understanding of insulin-glucose fluctuation
- Blood glucose excursion analysis
- Control variability grid analysis
About License
T1DMSPermanent license for single users.
Matlab / Simulink and Curve Fitting Toolbox are required to use it.
* We do not handle Matlab.Excuse me, but please be aware.
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